To observe the effects of Jiangni Qingre Huazhuo Prescription on the esophageal tissue CGRP in rats with non-erosive gastroesophageal reflux disease(NERD). Methods:Sixty male SD rats were divided into the normal group，model group，western medicine group and Chinese medicine group. The NERD rat model was prepared by chicken ovalbumin/aluminum hydroxide sensitization combined with esophageal acid perfusion. After 14 days of drug intervention，the pathological changes of esophageal tissue and the calcitonin gene related peptide(CGRP)of high-sensitivity-related signaling molecule was observed. Results:Compared with the normal group，the esophageal tissue epithelial cells in the model group were widened and a small amount of inflammatory cells were present. Compared with the model group，the expression of CGRP in the esophageal tissue of the rats in the Chinese medicine group and the western medicine group was significantly reduced. The decreased range of Chinese medicine group was more significant than that of the western medicine group. Conclusion:Jiangni Qingre Huazhuo Prescription can get therapeutic effects of non-erosive gastroesophageal reflux disease by inhibiting expression of CGRP and down-regulate the high sensitivity of esophagus.