To investigate the clinical effects of Tripterygium wilfordii combined with low dose hormone in the treatment of idiopathic membranous nephropathy. Methods:In this study，91 patients with idiopathic membranous nephropathy were selected from the nephrology department of Heilongjiang Academy of Traditional Chinese Medicine from August 2014 to November 2015 as the research object，and all the subjects were divided into the observation group and the control group by the random number table method. The control group was treated with tripterygium glycosides，and the observation group was treated with the same dose of Tripterygium wilfordii，and small dose hormone. The serum TC，TG，BUN，SCr，ALB，24 h urinary protein levels，clinical therapeutic effects and cumulative recurrence rate of 2 groups after treatment were compared between the 2 groups. Results:After treatment，the average blood TC，TG，SCr and urine 24 h protein in the 2 groups were significantly lower than those before the treatment，and the blood ALB level was significantly higher than that before the treatment. The average TC，TG，SCr and 24 h urine protein in the observation group was significantly lower than the control group，and the serum ALB level was significantly higher than that in the control group. The difference was statistically significant(P<0.05). The total effective rate of the observation group was significantly higher than that of the control group(χ2=4.561，P=0.033<0.05)，and the difference was statistically significant(P<0.05). After treatment，the cumulative recurrence rate of 2 years in the patients with idiopathic membranous nephropathy(6.82%，3/44 vs 25.53%，12/47，Log-rank χ2=5.063，P=0.024<0.05)was significantly lower than that of the control group，and there was a statistically significant difference(P<0.05). Conclusion:Tripterygium wilfordii combined with low dose hormone in the treatment of idiopathic membranous nephropathy has good clinical curative effects and good prognosis. It is worthy of clinical application.