To investigate the effects of Maxing Shigan Decoction combined with cetirizine hydrochloride on the hemorheological indexes and antioxidant capacity for the patients with chronic urticaria. Methods:A total of 92 patients with chronic urticaria were selected from May 2016 to May 2017 in Benxi Central Hospital. According to the different methods，they were divided into the control group(n=44)and the observation group(n=48). The control group was treated with cetirizine hydrochloride alone. The observation group，based on the control group，was treated with Maxing Shigan Decoction. The antioxidative indexes，clinical symptoms and hemorheological indexes in the 2 groups were observed before and 4 weeks after the treatment. The adverse reactions were observed before and after 4 weeks of treatment. Results:1)In the observation group after medication，CP(1.59±0.15)mpa.s，ESR(32.54±2.02)mm/h，Fg(2.35±0.27)g/L，HSV(4.79±0.62)mpa.s，LSV(6.28±0.39)mpa.s，Hct(0.42±0.10)% were significantly lower than that of the control group(P<0.05). 2)In the observation group after medication，SOD(172.54±23.15)U/mL，VitE(49.18±3.55)mg/gprot，MT(56.62±2.01)mg/g，CAT(342.13±17.62)U/g，GSH-Px(37.17±4.28)mg/mL were significantly higher than that of the control group(P<0.05). MDA(3.16±0.84)nmol/mL，T-AOC(5.80±1.26)U/mL，ROS(759.12±14.74)U/mL were significantly lower than that of the control group(P<0.05). 3)The score of clinical symptoms in the observation group was(6.15±0.24)，which was significantly higher than that of the control group(7.78±0.21)(P<0.05). 4)The adverse reaction rate in the observation group(4.16%)was significantly lower than that of the control group(18.18)(P<0.05). Conclusion:For chronic urticaria，on the basis of simple cetirizine hydrochloride，the Chinese herbal medicine Maxing Shigan Decoction can obviously improve the curative effects as well as the indexes of antioxidation，hemorheology with high safety.