To explore the effevts of Yangxue Huoxue Recipe combined with western medicine on serum-related cytokines，platelet parameters and bone metabolism of children with idiopathic thrombocytopenia purpura (ITP).Methods:A total of 103 cases of children with ITP in Yongcheng People's Hospital were selected and divided randomly into observation group (n＝51) and control group (n＝52).Control group was treated with prednisone acetate tablets and cyclosporine tablets，and observation group was treated with Yangxue Huoxue Recipe on the basis of control group.Both groups were treated for 3 months continuously.The clinical efficacy of the 2 groups was statistically analyzed.The TCM symptom quantification integral，serum cytokines，platelet parameters and bone metabolism indexes of 2 groups before and after treatment were compared.Results:After treatment，the total effective rate of observation group was 94.12%，which was obviously higher than the 76.92% of control group (P<0.05); Compared with before treatment，the TCM symptom quantification integral of 2 groups decreased significantly，and observation group was obviously lower than control group (P<0.01); Compared with before treatment，the serum IL-4，IL-6，INF-γ and TNF-α levels of 2 groups decreased significantly after treatment，and observation group was obviously lower than control group (P<0.01); Compared with before treatment，the PLT，PCT of 2 groups increased significantly，and observation group was obviously higher than control group (P<0.05 or P<0.01).The PDW，MPV of 2 groups decreased significantly，and observation group was obviously lower than control group (P<0.01); There was no obvious difference in the levels of serum PⅠCP and urinary DPD in observation group before and after treatment (P>0.05).The serum PⅠCP concentration decreased significantly and the urinary DPD excretion rate increased significantly than before treatment of control group after treatment，and there was statically significant difference between 2 groups (P<0.01).Conclusion:Yangxue Huoxue Recipe combined with western medicine in the treatment of ITP can relieve effectively the TCM symptoms of ITP children，reduce the serum cytokines，improve the platelet parameters and bone metabolism，promote the rehabilitation of ITP children.Its clinical curative effect is remarkable.