To observe the clinical efficacy of Sihe Decoction in the treatment of patients with non-alcoholic fatty liver disease(NAFLD)and its influences on relevant biochemical indexes，as well as to explore its therapeutic mechanism，providing references for the selection of treatment options for clinical patients with NAFLD. Methods:A total of 50 patients with NAFLD were selected from January 2015 to January 2017 in Wangjing Hospital of Chinese Academy of Chinese Medical Sciences. They were numbered according to the order of consultation. The single number was set as the control group，and the double number was set as the observation group，with 25 cases in each group. Two groups of patients were given daily life guidance and Feili Ganning Tablet. Moreover，the observation group patients，on the basis of the control treatment，were given modified Sihe Decoction. Patients in the 2 groups were treated for 12 weeks as a course of treatment. The changes of serum alanine aminotransferase(ALT)，serum glutamate aminotransferase(AST)，serum transforming growth factor-beta 1(TGF-β1)，superoxide dismutase(SOD)，serum inflammatory factors such as interleukin-6(IL-6)，interleukin-8(IL-8)，tumor necrosis factor-alpha(TNF-alpha)and liver color Doppler ultrasound scores before and after treatment were compared between the 2 groups. Therapeutic effects and adverse drug reactions/side effects in the course of treatment were compared. Results:1)After treatment，the levels of serum ALT，AST and TGF-β 1 in the 2 groups were significantly lower than those before treatment. The levels of TGF-β1 in the observation group were significantly lower than those of the control group(P<0.05). There was no significant difference between ALT and AST groups(P>0.05). After treatment，the levels of serum SOD in the 2 groups were significantly higher than those of the control group(P<0.05); 2)After treatment，the serum inflammatory factors IL-6，IL-8 and TNF-α in the 2 groups were significantly lower than those before treatment. Those in the observation group was significantly lower than that of the control group(P<0.05); 3)After treatment，the liver color B-ultrasound scores of the 2 groups were lower than those before treatment. Those in the treatment group was lower than that of the control group(P<0.05); 4)After treatment，the total clinical effective rate of the observation group was significantly higher than that of the control group(P<0.05); 5)There was no significant difference in the rate of adverse reactions between the 2 groups(P>0.05). Conclusion:Modified Sihe Decoction has obvious hepatoprotective on non-alcoholic fatty liver. It can reduce enzymes as well as improve the degree of liver histopathological changes of non-alcoholic fatty liver.