To investigate the clinical effects of Angong Niuhuang Pills combined with nimodipine for the treatment of hypertensive intracerebral hemorrhage(HICH). Methods:From April 2016 to April 2017，92 patients with HICH were selected in Second Traditional Chinese Medicine Hospital of Shenyang. According to the different medication schemes，they were divided into the observation group(47 cases)and the control group(45 cases). The observation group was treated with Angong Niuhuang Pills combined with nimodipine，and the control group was treated with nimodipine alone. The serum neurotransmitters were detected before and after 7 days of the treatment in both groups. After 3 months of treatment，the changes of Barthelindex，stress hormone index were detected and the side effects were recorded within 7 days during the treatment. Results:1)In the study group after medication，the serum neurotransmitters NTF(5.64±0.91)ng/mL，GABA(9.14±1.15)μmol/L，NGF(87.92±3.64)pg/mL were significantly higher than those of the control group. Glu(70.89±3.04)μmol/L，NPY(169.46±7.32)μg/L，NSE(12.58±1.08)μg/L，Gly(227.52±17.63)μmol/L，Asp(27.23±1.58)U/L were significantly lower than those of the control group(P<0.05). 2)In the study group，the serum stress hormone index AD(0.50±0.16)ng/mL，Cor(275.12±10.25)nmol/L were significantly higher than that of the control group. CRH(7.54±1.26)pmol/L，NE(322.13±10.62)ng/L，Ang-Ⅱ(41.62±3.01)ng/L，ACTH(6.54±0.75)pmol/L，MDA(3.22±0.46)nmol/mL，AVP(2.18±0.67)ng/L were significantly lower than that of the control group(P<0.05). 3)The total Barthel index score of the study group(81.15±4.62)was significantly higher than that of the control group(64.48±3.78)(P<0.05). 4)There was no significant difference in the adverse reaction rate between the study group(14.89%)and the control group(17.78%)(P<0.05). Conclusion:For the patients with HICH，on the basis of the western medicine nimodipine，the addition of Angong Niuhuang Pills can effectively improve the neurotransmitter，stress hormone expression and improve the ability of daily life for patients，and the side effects are less.