To compare the clinical preventive and therapeutic effectS of Biantong capsule and Maren capsule on patients with constipation induced by antipsychotic，and provide a basis to treat patients with constipation induced by antipsychotic. Methods:A total of 120 schizophrenic patients admitted to Henan Psychiatric Hospital from January 2016 to December 2017 were selected. The patients were randomly divided into the control group and the observation group，with 60 cases in each group. The patients in the observation group were given Biantong capsules while patients in the control group were given Maren capsules. Two weeks as a course of treatment，there were two weeks in the treatment between the rest，treatment and follow-up for a year. The constipation inefficient，the incidence of constipation，average constipation frequency and adverse reactions of the 2 groups were observed. Results:The constipation inefficient，the incidence of constipation and average constipation frequency in the observation group were lower than that of the control group，and the difference was statistically significant(P<0.05). The adverse reaction rate of the observation group was lower(P<0.05). Conclusion:There has good effects of the Biantong capsule to treat constipation induced by antipsychotic，which was better than Maren capsules and the adverse reactions was lower. It is a safe and effective drug to treat constipation induced by antipsychotic and worth wide use in the clinical practice.