To study the clinical efficacy of Tongdu Ningshen Decoction combing with 24 Style Taijiquan exercise in the treatment of insomnia with syndrome differentiation of maladjustment of Du meridian. Methods:A total of 80 patients with insomnia with syndrome differentiation of maladjustment of Du meridian from Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from September 2017 to June 2018 were selected and randomized into the observation group and the control group，with 40 cases in each group. The observation group was treated by Tongdu Ningshen Decoction combining with 24 Style Taijiquan exercise，and the control group was treated by Tongdu Ningshen Deciction combined with CBT-I. Two groups were treated for 8 weeks. Pittsburgh sleep quality index(PSQI)and clinical symptoms scale of TCM were used to evaluate the efficacy before and after the treatment. Results:Both groups witnessed a significant decline in scores in PSQI and clinical symptoms scale of TCM(P<0.01); The treatment group performed significantly better in reliving symptoms including dizziness，headache，chest tightness，palpitation，mental exhaustion，forgetfulness，and stiff neck(P<0.01). Conclusion:Tongdu Ningshen Decoction combing with 24 Style Taijiquan exercise can relieve the symptoms of insomnia with syndrome differentiation of maladjustment of Du meridian.