To explore the clinical efficacy of acupuncture combined with Xuefu Zhuyu Capsule in the treatment of patients with thromboangitis obliterans(TAO). Methods:A total of 95 cases TAO patients admitted to Panjin Central Hospital from March 2017 to April 2018 were selected and randomly divided into the control group(n=47)and observation group(n=48)according to random number table methods. The control group was treated with western medicine treatment，while the observation group was treated with acupuncture and Xuefu Zhuyu Capsule treatment on the basis of the control group. The 2 groups were treated for 6 weeks continuously. The clinical curative effects in the 2 groups were calculated after treatment; the traditional Chinese medicine(TCM)syndrome scores in the 2 groups were compared before and after treatment; the serum ET-1，NO and hs-CRP levels in the 2 groups were detected before and after treatment; the maximum walking distance and ABI value in the 2 groups were observed before and after treatment. Results:The clinical total effective rate in the observation group after treatment was 91.67%，which was significantly higher than 65.96% of the control group(P<0.01); compared with scores before treatment，the limb pain，limb numbness，limb cooling，intermittent claudication，limb end skin color scores in the 2 groups significantly decreased after treatment(P<0.05 or P<0.01)，and the observation group was significantly lower than that of the control group(P<0.01); compared with levels before treatment，the serum ET-1 and hs-CRP levels in the 2 groups significantly decreased after treatment(P<0.01)，the serum NO levels significantly increased(P<0.05)，and there was a significant difference between the 2 groups(P<0.01); compared with values before treatment，the ABI value in the 2 groups and maximum walking distance in the observation group increased significantly after treatment(P<0.01). The observation group was significantly higher than that of the control group(P<0.01). Conclusion:Acupuncture combined with Xuefu Zhuyu Capsule can effectively alleviate the symptoms of TAO patients，inhibit the inflammatory reaction as well as improve the vascular endothelial cells function and lower limbs function. Its efficacy is superior to western medicine treatment.