To explore the high risk factors of breast cancer from the perspective of Traditional Chinese Medicine (TCM) Constitution，and to provide new ideas and approaches for the prevention and early treatment of breast cancer.Methods:A large sample descriptive epidemiological cross-sectional study and a non-matched case-control study were conducted.From October 2014 to December 2016，a total of 504 cases of breast cancer patients (case group) at the First Affiliated Hospital of the First Affiliated Hospital of Shenzhen University and 504 healthy women (control group) at the same time were studied.The general data of the subjects，the type of TCM constitution and the distribution of syndromes were analyzed by questionnaire survey The basic data of the 2 groups and the types of TCM Constitution were compared，and the correlation between the constitution of Chinese medicine and the TCM syndrome type of the patients with breast cancer was summarized，and the relationship with the survival time of the patients with breast cancer was analyzed.Results:There were 102 cases of yin-deficiency constitution (20.24%)，98 cases of qi-depression constitution (19.44%)，72 cases of phlegm-wet constitution (14.29%)，from high to low in the first three cases.The survival time of breast cancer patients with different Chinese physique types was different (χ2=32.044，P=0.000)，among which the survival time of yin-deficiency constitution was the shortest and the second was qi-depression constitution.Conclusion:The patients with breast cancer mostly have either of these 2 kinds of constitution，qi-depression or yin-deficiency，which suggest that chronic stagnation of the liver is unfavorable to the chest and choroid machine，and it is closely related to the occurrence of breast cancer.