To study the multi-residues detection methods for Salvia miltiorrhiza by LC-MS/MS.Methods:A method using a modified QuEChERS and d-SPE clean-up followed by LC-MS/MS has been established for the quantitative determination of the residues.The extract was determined by LC-MS/MS in multi-reaction monitoring(MRM）mode，and internal standard method was applied to quantify the pesticides.Results:All the 139 pesticides showed good linearity in the range of 0.005～0.2 mg/L.The average recoveries of the pesticides at the spiked levels of 10，50，100 μg/kg ranged from 70.2～126.1% with the RSDs of 1.2～19.5%，except for Thiabendazole(67.2～67.9%).The limits of detection(LODs）of 139 pesticides were 0.005～0.05 mg/kg.The results demonstrated that this method was simple，rapid and suitable for the determination of 139 pesticide residues in Salvia miltiorrhiza.Conclusion:The analytical sensitivity and accuracy can meet the requirements of multiple pesticide residue analysis.