To investigate the clinical efficacy of Tianma Gouteng Decoction as auxiliary treatment in the treatment of acute cerebral infarction with TCM pattern of phlegm and stasis blocking collaterals，and to study the changes in patient's vascular endothelial function，levels of homocysteine(Hcy)，D-dimer and hypersensitivity C-reactive protein(hs-CRP).Methods:A total of 102 patients with acute cerebral infarction treated in Jiangsu Province Hospital of Chinese Medicine from March 2016 to March 2018 were selected.According to the random number table method，the patients were divided into two groups，with 51 cases in the control group and 51 cases in the treatment group.The control group was treated with conventional western medicine，while the treatment group was treated with Tianma Gouteng Decoction on top of the treatment performed in the control group.The treatment course of both groups were 14 d.The therapeutic effect，NIHSS score，Balthel index，endothelial function，Hcy，D-dimer and hs-CRP levels before and after treatment were compared between the 2 groups.Results:The total effective rate of the treatment group(92.16%）was higher than that of the control group(70.59%)，and the difference was statistically significant(P<0.05).After the treatment，in both groups，the score of NIHSS was lower than that before the treatment，and the score of Balthel index was increased compared with that before the treatment(the control group：t=13.427，17.445，the treatment group：t=22.986，22.959，P<0.05); and after the treatment，the NIHSS score in the treatment group was lower than that of the control group，while its Balthel index score was higher than that of the control group(t=17.375，12.702，P<0.05).The levels of ET-1 in the 2 groups were lower than that before the treatment，and the levels of NO were increased compared with that before treatment(control group：t=11.236，7.209，treatment group：t=16.042，19.336，P<0.05); and after the treatment，the level of ET-1 in the treatment group was lower than that of the control group，while the NO level was higher than that of the control group(t=8.159，7.801，P<0.05).After the treatment，the levels of serum Hcy，D-dimer and hs-CRP were lower in the 2 groups than before the treatment(control group：t=10.854，8.630，12.002，treatment group：t=24.812，20.559，18.890，P<0.05); after the treatment，the serum Hcy，D-dimer and hs-CRP levels were lower in the treatment group than in the control group(t=10.642，12.775，10.884，P<0.05).Conclusion:The clinical efficacy of Tianma Gouteng Decoction as auxiliary treatment in the treatment of acute cerebral infarction with TCM pattern of phlegm and stasis obstructing collaterals is significant.It can improve patient's vascular endothelial function and reduce the levels of Hcy，D-dimer and hs-CRP，which is worthy of clinical reference.