To explore the effects of Yangxinshi on hemodynamics and oxidative stress in patients with chronic heart failure based on optimized drug therapy.Methods:Eighty patients of acute heart failure admitted to the Department of Cardiology，Zhongshan Hospital Affiliated to Dalian University from October 2017 to April 2018 with stable condition for 2 to 4 weeks and informed consent were enrolled in this study.They were randomly divided into the control group，the Yangxinshi group，with 30 in each group，the Trimetazidine group and the Yangxinshi+ Trimetazidine group，with 10 in each group.The left ventricular ejection fraction(LVEF）and stroke volume(SV）were measured by non-invasive cardiac blood flow tester.Changes in oxidative stress indicators such as catalase(CAT)，succinate dehydrogenase(SDH)，glutathione-peroxidase(GsH-Px)，malondialdehyde(MDA)，and superoxide dismutase(SOD）were measured by enzyme-linked immune sorbent assay(ELISA).SPSS 24 software was used to process data.T test was used to analyze the data at baseline and 6 months' follow-up in the groups.One-way ANOVA analysis was used to compare the indicators of 6 months' follow-up.The project has been registered in Clinical trail(Registration number：NCT03333499）and examined by the Ethics Committee of Zhongshan Hospital Affiliated to Dalian University.Results:During 6 months follow-up，the LVEF and SV values of the Yangxinshi group，Trimetazidine group，Yangxinshi and Trimetazidine group were significantly improved compared with the baseline of the same group(P<0.05).The LVEF and SV values of the 3 groups were significantly higher than those of the control group(P<0.05).The CAT，SDH，GsH-Px and SOD of the 4 groups were significantly increased than those of the same group(P<0.05); MDA was significantly decreased than the baseline of the same group(P<0.05).The Yangxinshi group，Trimetazidine group，Yangxinshi and Trimetazidine group were significantly improved in oxidative stress-related factors such as CAT compared with the control group(P<0.05); There was no statistical differences among them.Conclusion:On the basis of optimizing drug treatment，Yangxinshi can improve blood pressure of patients with chronic heart failure，the patient's hemodynamics and the heart function，as well as reduce the body's oxidative stress damage with high safety，which can be applied clinically.