To observe the clinical efficacy of Qili Powder in the treatment of ankle fracture，and to analyze its effects on the ankle joint related indexes and functions.Methods:A total of 80 patients with ankle fracture treated in Baoji Hospital of Chinese Medicine from January 2016 to December 2017 were selected.They were randomly divided into the treatment group and the control group，with 40 cases in each group.The control group was treated with percutaneous cannulated screw fixation，while the treatment group received the same procedure combined with the Qili Powder.The patients' ankle joint function(Kofoed，AOFAS score)，clinical symptoms(time of swelling disappearance，fracture healing and full weight-bearing)，isokinetic muscle strength，serum Ca2+，ALP，IL-6 and TNF-α level before，after and 4 months' follow-up after the treatment were assessed respectively，and the comparative analysis was performed.Results:1）After，and in the 4 months' follow-up after treatment，the Kofoed and AOFAS scores of both group were significantly improved compared with before treatment(P<0.05)，and the treatment group had greater improvement than the control group(P<0.05);2）After the treatment and in the follow-up 4 months after，patients of both group had significantly decreased serum IL-6 and TNF-α levels，and the treatment group had greater decrease than the control group(P<0.05).3）After treatment and in the follow-up，the Ca2+ and ALP levels of 2 groups were higher than those before treatment(P<0.05); and that of the treatment group was significantly higher than the control group(P<0.05).4）In the follow-up after 4 months，the average time of disappearance of pain and swelling，fracture healing and full weight-bearing of patients in the treatment group was significantly shorter than that of the control group(P<0.05).5）In the 4 months of follow-up，during dorsiflexion，flexion，varus and valgus，patients in the treatment group had significantly increased torque acceleration energy，relative peak torque，endurance when compared to the control group(P<0.05).Conclusion:Ankle fracture surgery，combined with Qili Powder，can effectively improve the clinical symptoms，pain，swelling and fracture healing time，and significantly improve ankle joint function and muscle strength，which may be contributed by the functions of invigorating blood and dissolving stasis，boosting fracture healing，and removing of inflammatory factors，etc.