To clinically observe the effects of Jianpi Quzhuo Xiaoji Granules in the treatment of chemotherapy-associated diarrhea of advanced colorectal cancer.Methods:A total of 22 patients with advanced colon cancer admitted in the oncology department of Yantai Hospital of Traditional Chinese Medicine from September 2016 to June 2018 were included as the study object.Single case randomized controlled trial was adopted，and 2 patients dropped out during the trial.Eventually，20 patients were included，with 80 cases of chemotherapy and both 40 cases in the observation group and the control group after unblinding.After the treatment，the adverse effects of chemotherapy of the 2 groups were counted.The scores of TCM syndromes before and after treatment of the 2 groups were compared，as well the evaluation as of curative effect and the quality of life.Results:The effect of relieving TCM syndrome of the observation group was significantly better than that of the control group(P<0.05).After the treatment，the scores of all functions of the observation group and the body function of the control group were significantly increased，and the scores of the observation group were significantly higher than that of the control group(P<0.01).The scores of all symptoms of the treatment group and the role function and TCM symptoms of the control group were significantly decreased，and the scores of the treatment group were significantly lower than those of the control group(P<0.05 or P<0.01).Compared with before the treatment，the observation group after the treatment had significantly lower scores in terms of decreased food intake and digestion，fatigue，abdominal pain，abdominal distension，diarrhea; and the control group had significantly lower scores in terms of abdominal pain，abdominal distension and diarrhea，and the scores of the treatment group was significantly lower than that of the control group(P<0.05 or P<0.01).The total incidence of adverse effects in the treatment group was significantly lower than that in the control group(P<0.01).Conclusion:Jianpi Quzhuo Xiaoji Granules can alleviate the clinical symptoms of patients with advanced colorectal cancer after chemotherapy，especially chemotherapy-associated diarrhea，reduce the toxic and adverse effects of chemotherapy，improve their quality of life and compliance，which is worthy of promotion and clinical application.