To investigate the clinical curative effects of integrated medicine in the treatment of gastric cancer patients and its effects on tumor markers，immunity and the quality of life.Methods:A total of 64 patients with gastric cancer treated in Jiangsu Province Hospital of Chinese Medicine from December 2014 to December 2017 were selected and divided into the observation group(32 cases）and the control group(32 cases）according to random number table method.The control group received FOLFOX4 chemotherapy，while the observation group were given Chinese medicine decoction in addition to the same chemotherapy.Both groups received 6 courses of treatment，and the length of each course was 21 days.The curative effects，the changes in the levels of serum tumor markers and immunity before and after the treatment，the scores of life quality and the incidence of adverse reactions were compared between the 2 groups.Results:The total effective rate of the observation group(75.00%）was higher than that of the control group(46.87%)(P<0.05).The serum CEA，CA199 and CA125 levels of the 2 groups decreased after the treatment(the observation group：t=21.662，21.964，16.706; the control group：t=8.780，13.012，9.984，P<0.05); the serum levels of CEA，CA199 and CA125 of the observation group were lower than those of the control group(t=13.992，11.731，7.302，P<0.05).After the treatment，the levels of CD4+ and CD4+/CD8+ increased，while the level of CD8+ decreased(t=7.582，6.936，9.204，P<0.05）in the observation group; in the control group，CD4+ and CD4+/CD8+ decreased while CD8+ increased(t=5.453，5.821，11.297，P<0.05）after the treatment; after the treatment，the CD4+ and CD4+/CD8+ levels of the observation group were higher than those of the control group，while the level of CD8+ was lower than that of the control group(t=11.590，16.718，17.623，P<0.05).The scores of life quality of the observation group were higher than those of the control group(P<0.05).The incidence of gastrointestinal reactions，liver and kidney dysfunction，thrombocytopenia and leukocytopenia in the observation group were lower than those in the control group(P<0.05).Conclusion:The effects of integrated medicine in the treatment of gastric cancer patients is significant.It can reduce the serum levels of CEA，CA199 and CA125，enhance immunity and improve the quality of life of the patients.It is worthy of clinical reference.