To analyze the effects of adjuvant chemotherapy with Xiaochaihu Decoction on life quality，immunity，inflammatory effect and toxic and adverse effects of chemotherapy in patients with advanced lung cancer and its clinical prognosis，and to provide reference for the making of plans for the improvement of life quality of advanced lung cancer patients.Methods:A total of 50 patients with advanced non-small cell lung cancer(NSCLC）receiving systemic chemotherapy in Henan Cancer Hospital from January 2015 to January 2018 were included in this study.They were numbered according to the inclusion order and divided into two groups：patients with odd numbers went to the control group and those with even numbers were in the observation group，with 25 cases in both groups.Both groups were treated with GP chemotherapy(gemcitabine+cisplatin and antitoxic drugs：ondansetron+metoclopramide+dexamethasone+furosemide+vitamin C）for three weeks per course and two consecutive courses.On the basis of the above treatment，the patients in the observation group were additionally treated with modified Xiaochaihu Decoction according to individual pattern before and during the course of chemotherapy until the end.Quality of life score(KPS）and the result of life quality improvement，immune function indexes(CD3+，CD4+，CD8+，CD4+/CD8+)，serum inflammatory indexes(IL-6，IL-10，IL-13，S100A8，S100A9）of the 2 groups were compared before and after treatment.Toxic and adverse effects were documented and compared between the 2 groups during the treatment.The clinical efficacy was evaluated and compared after the completion of treatment.Results:1）After treatment，the total effective rate of clinical prognosis of the observation group was significantly higher than that of the control group(P<0.05);2）After treatment，the KPS score of the observation group was significantly higher than that of the control group(P<0.05).The difference of KPS score before and after the treatment of the control group was of no statistical significance(P>0.05).The improvement rate of quality of life in the observation group was significantly higher than that in the control group，and the decrease rate was significantly lower than that in the control group(P<0.05).3）The levels of serum inflammatory factors IL-6，IL-10，IL-13，S100A8 and S100A9 were decreased after the treatment，and that of the observation group was significantly lower than the control group(P<0.05).4）After treatment，the levels of CD3+，CD4+，CD4+/CD8+ in the observation group were significantly higher than before，and the levels of CD8+ in the 2 groups were both significantly lower than before(P>0.05); there was no statistically significant difference in the control group before and after treatment(P>0.05).5）During the treatment，the adverse effect rate of the control group was significantly higher than that of the observation group(P<0.05).Conclusion:Xiaochaihu Decoction can effectively reduce the inflammatory effect，enhance immune function，improve the clinical efficacy and quality of life of patients with advanced lung cancer，and effectively reduce the toxicity and adverse effects of systemic chemotherapy.It is an effective adjuvant treatment for patients with advanced lung cancer in systemic chemotherapy and has high clinical value.