To investigate the effects of knee arthroscopic debridement combined with Huoxue Quyu Decoction on bone metabolism and inflammatory factors in patients with knee osteoarthritis. Methods:A total of 68 patients with knee osteoarthritis undergoing arthroscopic debridement in orthopedics department of Fushun Hospital of Chinese Medicine from June 2013 to May 2016 were selected and were divided into the control group and the observation group according to their different treatment methods. There were 34 patients (62 knees) without other treatment included into control group, and 34 patients (58 knees) receiving the treatment of Huoxue Quyu Decoction included into observation group. The outcomes in 6-month follow-up period of the two groups were compared. Results:After 6 months of treatment, the total effective rate in the observation group was significantly higher than that in the control group (81.02% vs 48.55%, P<0.05); The TCM syndrome scores of the observation group such as pain during the bed rest, morning stiffness or aggravation after waking up, twisting, swelling, and claudication were better than those in the control group (P<0.05). After treatment, the TNF-α and IL-6 levels in the observation group were significantly improved, and the difference between the observation group and the control group was statistically significant (P<0.05). The levels of COMP, CTX-II, CTX-I and MMP-3 in both groups were significantly improved after treatment, and were better in the observation group than those in the control group (P<0.05). Conclusion:Compared with the arthroscopic debridement treatment alone, the arthroscopic debridement combined with Huoxue Quyu Decoction can reduce the inflammatory factors level, ameliorate the levels of COMP, CTX-II, CTX-I and MMP-3 for patients with knee osteoarthritis, which is worthy of promotion.