To observe the effects of Xuefu Zhuyu decoction combined with acupuncture and moxibustion on intracranial hemodynamics, limb motor function and quality of life in hemiplegic patients with cerebral ischemic stroke (CIS). Methods:A total of 150 cases of patients with CIS were divided into the observation group and the control group with 75 cases in each group according to the random number table method. The observation group was treated with Xuefu Zhuyu decoction combined with acupuncture and moxibustion, while the control group was treated with conventional therapy. The mean blood flow velocities (Vm) of the anterior cerebral artery (ACA), middle cerebral artery (MCA) and posterior cerebral artery (PCA) were detected in the two groups before treatment (T1) and after 1 month of treatment (T2), and the limb motor function ［Fugl-Meyer Motor Function Assessment (FMA)］ and quality of life ［Stroke Specific Quality of Life Scale (SS-QOL)］ were evaluated, and the levels of related serum biochemical indexes ［erythropoietin (EPO), matrix metalloproteinase-9 (MMP-9), homocysteine (Hcy)］ were assessed in the two groups, and TCM symptoms scores (dark red tongue, dark lips and gums, dark purple claws, gloomy complexion, hemianesthesia, swelling of hands and feet) were compared between the two groups. Results:At T2, the Vm of ACA, MCA and PCA, and serum levels of EPO, MMP-9 and Hcy, and the TCM symptoms scores in two groups were lower than those at T1, and the indexes were lower in the observation group than those in the control group, and the difference was statistically significant (P<0.05). The scores of FMA and SS-QOL were higher than those at T1, and the scores in the observation group were higher than those in the control group (P<0.05). Conclusion:Xuefu Zhuyu Decoction combined with acupuncture and moxibustion can significantly improve the intracranial hemodynamic status, limb motor function, quality of life and TCM symptoms of CIS hemiplegia patients, relieve brain tissue damage and help to promote the recovery of disease.