To multi-point observe the clinical effect of IgA nephropathy in the optimized treatment by tonifying and replenishing liver and kidney integration traditional Chinese and western medicine.Methods:A total of 80 patients with IgA nephropathy admitted to mutil-centers from June 2016 to June 2018 were selected as subjects.According to the principle of randomized control,they were divided into an observation group and a control group,with 40 cases in each group.The observation group was treated by traditional Chinese medicine granules+Losartan,and the control group was treated by traditional Chinese medicine mimicking agent+Losartan.The 24 hours urinary protein quantitation,urinary albumin/creatinine(MA/Cr),serum creatinine(Scr)and glomerular filtration rate(eGFR)were measured every 8 weeks and perform a therapeutic evaluation,for a total of 24 weeks of observation.Results:The total effective rate was 80.0% in the observation group and 35.0% in the control group,and the difference between the 2 groups was statistically significant(P<0.05).The 24-hour urine protein quantitation,MA/Cr and Scr in the observation group were decreased gradually with extension of the treatment time,which was statistically different compared with the control group(P<0.05).eGFR in the observation group was gradually increased with the extension of treatment time,which was statistically significant compared with the control group(P<0.05).Conclusion:The integration traditional Chinese and western medicine optimized treatment group is significantly better than the western medicine alone observation group in reducing proteinuria and protecting renal function,and the advantages are further revealed with extension over time.