Renal fibrosis can be manifested as glomerular sclerosis,renal tubulointerstitial fibrosis,renal vascular sclerosis and renal extracellular matrix(ECM)accumulation,with inflammatory cell infiltration,abnormal secretion of pro-inflammatory factors,and damage to the kidney's natural cells,activation,proliferation,and apoptosis are closely related.Renal fibrosis involves multiple signaling pathways including TGFβ1-Smad,MAPK,Wnt/β-catenin,and PI3K/Akt/mTOR,etc.The common effector molecule has a crosstalk mechanism between the pathways,and there is no effective drug to control.In the past 10 years,traditional Chinese medicine has accumulated rich experience in the prevention and treatment of renal fibrosis.The research on renal fibrosis signaling pathway has also become a mechanism and target means for screening and studying traditional Chinese medicine.