To observe the clinical efficacy of patients with phase III diabetic nephropathy before and after treatment with Yishen Huoxue Xiezhuo decoction alone and combined with Lu's acupuncture and moxibustion.Methods:Using a prospective randomized controlled clinical study approach,90 patients of diabetic nephropathy admitted to the Seventh People's Hospital of Chinese medicine from January 2017 to December 2018 were selected as subjects.According to the principle of randomized control,they were divided into group A:western medicine control group was given conventional western medicine,group B:Chinese and western medicine treatment group was given Yishen Huoxue Xiezhuo decoction on the basis of western medicine treatment,group C:Chinese and western medicine combined with Lu's acupuncture and moxibustion treatment group on the basis of Chinese and western medicine.All of the 3 groups were treated with 2 months as a course of treatment,and a total of 3 courses were treated.The urinary microalbumin,renal function(serum creatinine,glomerular filtration rate,blood uric acid)C-reactive protein,fibrinogen,insulin resistance index and inflammatory cytokines were observed before treatment and after 2,4 and 6 months after treatment,evaluating the efficacy and providing a scientific basis for the treatment of early diabetic nephropathy by Chinese and western medicine combined with Lu's acupuncture.Results:After comparing the indicators before and after treatment,the symptoms of patients in group A,B,and C were all relieved after treatment.The clinical effect in the group C was better than those in the group B,and the clinical effect in the group B was better than those in the group A,the physiological indexes of patients in group C were the most obvious,and the effect was the most significant.Conclusion:Chinese and western medicine combined acupuncture and moxibustion therapy is more effective in treating early diabetic nephropathy.