Based on the quantitative evaluation and analysis of compound Houttuynia cordata capsule based on multi-index components,it provides a reference for the quality control of compound Houttuynia cordata capsule.Methods:First,the compound Houttuynia capsule sample solution and quercetin were prepared,including Yichun,chlorogenic acid,forsythrin,baicalin reference solution,The chromatographic conditions were determined by high performance liquid chromatography(HPLC) with CAPCELL-PAK-MG-C18 column (5 μm, specification: 4.6 mm × 250 mm),column temperature 35 ℃,injection volume 10 μL,flow rate 1.0 mL/min). Gradient eluting was carried out under the conditions of mobile phase A (acetonitrile) and mobile phase B (water 0.01% phosphate).Optimize the methodological rigour of high performance liquid phase (HPLC),carry out linear regression, precision, reproducibility,stability,specificity test and sample recovery test,quantitative analysis of quercetin in samples with multiple index components,Quercetin, chlorogenic acid,The contents of phillyrin and baicalin.Results:1)the specific tests of Houttuynia cordata, Radix Isatidis, Flos Lonicerae, Forsythia suspensa and Scutellaria baicalensis were carried out by HPLC chromatography. the results showed that Houttuynia cordata, Radix Isatidis, Flos Lonicerae and Forsythia suspensa were found in the compound Houttuynia cordata capsule. Scutellaria baicalensis Georgi has a good specificity.2) the linear range of quercetin, phillyrin and chlorogenic acid were within the range of 4≤201 μg/mL, and the linear range of baicalin and baicalin were 12 μg/mL and 601 μg/mL, respectively. the linear range of quercetin, phillyrin and chlorogenic acid was 4≤201 μg/mL.3) the results of precision test showed that the relative standard deviation (RSD) of quercetin, phillyrin, chlorogenic acid and baicalin peak area were 0.45%, 0.52%, 0.66%, 0.59%, 0.31%, 0.51%, 0.52%, 0.56%, 0.59%, 0.31%, 0.52%, 0.62%, 0.59% and 0.31%, respectively. The results show that the precision of HPLC instrument under this chromatographic condition is good.4) The results of stability test showed that the relative peak area RSD of compound Houttuynia capsule solution was 1.33%, which indicated that the solution of compound Houttuynia capsule was basically stable within 24 hours.5) The results of reproducibility test showed that the relative peak area RSD of compound Houttuynia capsule solution was 0.92%, which indicated that the HPLC method had good reproducibility.6) The results showed that the average recovery of quercetin, eichun, chlorogenic acid, phillyrin and baicalin were 99.10%, 99.26%, 99.07%, 98.05%, 98.82%, 98.32%, 1.81% and 1.49%, respectively. 0.94%, 1.58%, 1.01%, indicating that the recovery is good.7)The results of quantitative determination based on multi-index components showed that the contents of quercetin, chlorogenic acid, phillyrin and baicalin in different batches of compound Houttuynia cordata Thunb capsules from different manufacturers were quite different.Conclusion:The results of quantitative determination based on multi-index components showed that the contents of quercetin, chlorogenic acid, phillyrin and baicalin in different batches of compound Houttuynia cordata Thunb capsules from different manufacturers were quite different.