To explore the effects of moxibustion on the expression of synaptic plasticity-related proteins in hippocampus of senescence accelerated mouse prone 8 (SAMP8).Methods:A total of 12 6-month-old male SAMP8 mice were randomly divided into a model group and a moxibustion group.In addition，6 male SAMR1 mice of the same age were used as a blank group.The blank and the model group were routinely grasped daily and fixed with a fixator，and no other treatment was performed; the mice in the moxibustion group were treated the same grasping and fixation，and Guanyuan (CV4) was given moxibustion.The intervention time of each group was 20 min/day，6 d/week，and a total of 6 weeks of intervention.After 6 weeks，the expression of synaptophysin (SYN)，brain-derived neurotrophic factor (BDNF)，tyrosine kinase receptor B (Trk B) and phosphorylated Trk B (p-Trk B) in hippocampus of the each group of mice were detected by Western blot.Results:Compared with the blank group，the expression of SYN，BDNF and p-Trk B in the hippocampus of the model group were significantly decreased (P<0.05).Compared with the model group，the expression of SYN，BDNF and p-Trk B in the hippocampus of the moxibustion group were significantly increased (P<0.05).There was no significant difference in the expression of Trk B in hippocampus between the 3 groups (P>0.05).Conclusion:Moxibustion intervention can play an anti-aging role by affecting the expression of synaptic plasticity-related proteins in the hippocampus of SAMP8 mice，and this effect may be achieved through BDNF/Trk B pathway.