To discuss the effects of qi-boosting and stasis-dissolving method on myocardial energy metabolism in rats with chronic heart failure.Methods:A total of 60 healthy male Wistar rats were divided into four groups，the sham-operation group，the valsartan group，the Chinese patent medicine group and the model group，with 15 rats in each group.Rat model of chronic heart failure with qi deficiency and blood stasis was established.Nine weeks after the model establishment operation，the model group，the Chinese patent medicine group，the Valsartan group and the sham-operation group began receiving experimental medical intervention：rats in the model group received intramuscular injection with 1 mL of normal saline every day for 4 weeks consecutively; the rats in the Chinese patent medicine group were intramuscularly injected with 0.5 mL of Astragalus membranaceus injection and Salvia miltiorrhiza injection respectively every day for 4 weeks consecutively; the Valsartan group was administered 20 mg/(kg·d）of Valsartan every day for 4 weeks consecutively，and the sham-operation group received intramuscular saline 1 mL every day for 4 weeks consecutively.The cross-sectional area of ventricular myocytes，cardiac function and changes of myocardial adenosine monophosphate of rats in each group were compared.Results:The cross-sectional area of ventricular myocytes in the model group，the Valsartan group and the Chinese patent medicine group was higher than that of the sham-operation group(P<0.05); the cross-sectional area of ventricular myocytes in the Valsartan group and the Chinese patent medicine group was lower than that of the model group(P<0.05); the cross-sectional area of ventricular myocytes in the Chinese patent medicine group was lower than that of the Valsartan group(P<0.05).The levels of LVEF and LVFS in the model group，the Valsartan group and the Chinese medicine group were lower than that of the sham-operation group，while the levels of LVESD and LVEDD were higher than that of the control group(P<0.05); the levels of LVEF and LVFS in the Valsartan group and the Chinese patent medicine group were higher than that of the model group，and the levels of LVESD and LVED were lower than that of the model group(P<0.05); the levels of LVEF and the LVFS in the Chinese patent medicine group were higher than those of the Valsartan group(P<0.05).There was no statistical significance in the levels of LVESD and LVED between the Chinese patent medicine group and the Valsartan group(P>0.05).The levels of ATP and ADP were lower in the model group，the Valsartan group and the Chinese medicine group than in the sham-operation group(P<0.05)，and the levels of ATP and ADP in the Valsartan group and the Chinese patent medicine group were higher than that in the model group(P<0.05); and the levels of ATP and ADP in the Chinese patent medicine group were higher than those of the Valsartan group(P<0.05).Conclusion:The qi-boosting and stasis-dissolving method can significantly improve myocardial energy metabolism in rats with heart failure，and has important research significance.