To evaluate the efficacy and safety of the lung-clearing and phlegm-dissolving method in the treatment of acute exacerbation of Chronic Obstructive Pulmonary Disease(COPD)，and to provide a basis for the treatment of acute exacerbation of COPD.Methods:Computer retrieval was conducted on the National Library of Medicine(PubMed)，EMBase，Cochrane Library，Chinese Journal Network(CNKI)，Wanfang database(Wanfang)，and the full text database of Chinese sci-tech periodicals(VIP)，etc.A comprehensive collection of clinical Randomized Controlled Trials(RCTs)，conducted before June 2018，of acute exacerbation of COPD with TCM prescriptions using the lung-clearing and phlegm-dissolving method，used alone or used in combination with conventional Western medicine as the experiment group with conventional Western medicine being the control group，was collected.The literature quality evaluation was performed via the bias risk assessment tool of the Cochrane Collaboration.After the independent evaluation and data extraction of two evaluators，Meta-analysis was performed on the main outcome indicators，including the clinical total efficiency，and the secondary outcome indicators，including pulmonary function(FVC，FEV1，FEV1%，FEV1/FVC）and blood gas analysis(PaO2，PaCo2)，etc.via RevMan 5.3 software.Results:In the total of 13 documents and 990 patients，496 cases in the treatment group and 494 in the control group，were included in this study with reported outcome indicators.The results of Meta-analysis showed that the efficacy of the lung-clearing and phlegm-dissolving method combined with conventional treatment of Western medicine was significantly higher than that of conventional Western medicine.The outcome indicators of lung function(FVC，FEV1，FEV1%，FEV1/FVC）and blood gas analysis(PaO2，PaCo2）were significantly improved compared with the control group，and the difference was statistically significant(P<0.000 01).However，due to the relatively short observation period of the included studies，adverse reactions of the Chinese medicine in the treatment groups were not reported.Conclusion:The lung-clearing and phlegm-dissolving method can improve the efficiency of the treatment of acute exacerbation of COPD，assist in improving the indicators of lung function and blood gas analysis，and better the quality of life of the patients.However，the quality of existing researches is relatively low，and the blinding is unsatisfactory and the blind method is poorly implemented，without covert grouping，so definite conclusions still await future RCTs of higher quality to be tested.