中医“益气养阴”法辅助治疗2型糖尿病的Meta分析
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陕西省自然科学基金面上项目(2015JM8447)


Effects of the Qi-boosting and Yin-nourishing(Yi Qi Yang Yin)Treatment as an Adjuvant Treatment of Type 2 Diabetes Mellitus:a Meta-analysis
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    摘要:

    目的:系统评价中医“益气养阴”法辅助治疗2型糖尿病的有效性。方法:选取PubMed,EMBase,CNKI和万方医学等数据库,搜集中医“益气养阴”法辅助治疗2型糖尿病的临床随机对照试验,采用STATA12.0软件对数据进行Meta分析。结果:共纳入13项研究,共888例患者。与对照组比较,中医“益气养阴”法可显著降低观察组患者空腹血糖(FPG)(WMD=-0.84,95%CI(-0.97,-0.71),P=0.000)、餐后血糖(PPG)(WMD=-0.73,95%CI(-1.16,-0.30),P=0.001)和糖化血红蛋白(HbA1c)(WMD=-0.17,95%CI(-0.32,-0.02),P=0.001)水平。三酰甘油(TG)和总胆固醇(TC)水平因研究间的高度异质性,仅进行描述分析。结论:中医“益气养阴”法有助于降低T2DM患者血糖和HbA1c水平。

    Abstract:

    To evaluate the effects of the qi-boosting and yin-nourishing(Yi Qi Yang Yin)treatment as an adjuvant treatment of type 2 diabetes mellitus(T2DM).Methods:By searching databases including PubMed,EMBase,CNKI and Wanfang,etc.,we gathered Randomized Controlled Trails(RCTs)associated with “Yi Qi Yang Yin” as an adjuvant treatment of T2DM.Statistical analysis was performed with STATA,ver.12.0.Results:Compared with the control group,statistical significance of the Qi-boosting and Yin-nourishing(Yi Qi Yang Yin)Treatment was found in the reduction of the levels of fasting plasma glucose(WMD=-0.84,95%CI(-0.97,-0.71),P=0.000),postprandial plasma glucose(WMD=-0.73,95%CI(-1.16,-0.30),P=0.001)and glycatedhaemoglobinA1c(WMD=-0.17,95%CI(-0.32,-0.02),P=0.001)of patients in the treatment group.The levels of triglyceride(TG)and total cholesterol(TC)among studies were highly heterogeneous,on account of which we only performed descriptive analysis.Conclusion:The Qi-boosting and Yin-nourishing(Yi Qi Yang Yin)Treatment is contributive in lowering the levels of plasma glucose and HbA1c of T2DM patients.Nevertheless,due to limited methodological quality and sample size,further high-quality studies are needed for more definitive conclusions.

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田会萍,任乐,姚鸿萍,张璐,封卫毅.中医“益气养阴”法辅助治疗2型糖尿病的Meta分析[J].世界中医药,2019,(05).

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  • 收稿日期:2017-02-10
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  • 在线发布日期: 2019-06-10
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