To investigate the therapeutic effects and prognosis of fluconazole injection combined with traditional Chinese medicine for recurrent maxillary sinus fungal infection after endoscopic sinus surgery.Methods:A total of 240 cases of recurrent maxillary sinus fungal infection admitted to the ENT department of the Third People's Hospital of Henan Province from January 2017 to January 2018 were selected as subjects,and they were randomly divided into an observation group and a control group,with 120 cases in each group.The observation group was treated with fluconazole injection combined with traditional Chinese medicine after endoscopic sinus surgery,and the control group was treated with nasal saline injection after endoscopic sinus surgery.By comparing the therapeutic effects evaluation after endoscopic sinus surgery,sinus nasal outcome test-20 (SNOT20) scale score,the indicators in the maxillary sinus after endoscopic sinus surgery in the 2 groups,the results of patient satisfaction survey,the clinical effects of fluconazole injection combined with traditional Chinese medicine intervention were evaluated.Results:The postoperative therapeutic effects evaluation in the observation group after endoscopic sinus surgery was better than that in the control group,and the difference was statistically significant (P<0.05).The nasal sinus was improved in both groups before and after treatment (P<0.05).After treatment,the sinus SNOT-20 score in the observation group was significantly lower than that in the control group,and the difference was statistically significant (P<0.05).The infiltration of inflammatory cells,interstitial edema,submucosal gland and goblet cell hyperplasia in both groups after treatment were better than those before treatment,and the observation group was significantly better than the control group.The difference was statistically significant (P<0.05).After treatment,the satisfaction rate in the observation group was significantly higher than that in the control group,and the difference was statistically significant (P<0.05).Conclusion:For the patients with recurrent maxillary sinus infection after endoscopic sinus surgery,the fluconazole injection combined with traditional Chinese medicine has a good effect on the treatment effect and prognosis of patients,which is of great significance to the function recovery and improving the quality of life of the patients.