To discuss the effects of Yinqi Ointment on the wound morphology and growth factors of diabetic foot ulcers.Methods:A total of 92 patients with diabetic foot ulcer with TCM pattern of deficiency of both qi and yin diagnosed by Peripheral Vessel Department of Dongzhimen Hospital from December 2016 to December 2017 were randomly divided into the treatment group and the control group(44 cases with 2 drop-outs in each group）On the basis of unified systemic treatment schedule and wound surface preparation，the treatment group was treated with Yinqi Ointment and the control group was treated with Kangfuxin Solution; after 4 weeks of treatment，the healing of ulcer，ulceration area，coverage area of granulation tissue and epithelial tissue and pain scores，as well as indexes as the dynamic analysis of VEGF，EGF and bFGF in local granulation tissue of the 2 groups of patients before and after the treatment were statistically analyzed.Results:The total effective rate of the treatment group was 88.37%，and the total effective rate of the control group was 74.42%.The wound reduction rate，epithelial tissue coverage，granulation tissue growth rate and local pain reduction rate after the treatment were significantly better than that of the control group(P<0.05).Through the detection of local granulation，increased VEGF，EGF and bFGF were all detected in both the treatment group and the control group，however，the treatment group has better effect in increasing growth factors than the control group.Conclusion:Yinqi Ointment can promote the healing of diabetic foot ulcers，and its mechanism may be related to the increase of growth factor content in granulation tissue.