To investigate the effects of Baihe Gujin Decoction and Livial on endocrine and neuroendocrine immune networks in menopausal syndrome patients, and provide reference for the clinical treatment of menopausal syndrome patients. Methods:A total of 86 patients with climacteric syndrome who were admitted to Qinghai Provincial Hospital of Traditional Chinese Medicine from March 2014 to May 2017 were randomly divided into the observation group and the control group, with 43 patients in each group. The control group was treated with Livial. The observation group was additionally treated with Baihe Gujin Decoction on the basis of the treatment of control group. The TCM (traditional Chinese medicine) symptom scores and Kupperman scores before and after treatment were compared between the two groups of patients. The changes of serum reproductive and endocrine hormone levels, neurotransmitters, and immune parameters before and after treatment were analyzed. The efficacy of TCM syndromes in the two groups was observed. Results:There was no significant difference in the levels of serum reproductive hormones, neurotransmitters, and immune parameters before treatment between the two groups (P>0.05). The TCM symptom scores, Kupperman scores, serum LH and FSH levels, 5-HT and NE neurotransmitters were significantly decrease in the two groups after treatment, while Serum E2 levels and IL-2 immune parameters were significantly increased. And in the observation group, the above indicators improved more significantly (P<0.05). The effective rate of treatment in the observation group was 95.35%, which was significantly higher than that in the control group. The difference was statistically significant (P<0.05). Conclusion:The combination of Baihe Gujin Decoction with Livial in the treatment of patients with climacteric syndrome can effectively regulate the neuroendocrine immune network, improve the secretion of estrogen, enhance the patient's immune system, and improve the clinical symptoms.