To explore the therapeutic effects of Yiqi Xiaozheng method in the treatment of coronary heart disease and its effects on ERK12 signal transduction pathway and Omentin-1.Methods:A total of 90 patients with coronary heart disease treated in the Zhengzhou Central Hospital Affiliated to Zhengzhou University from March 2017 to March 2018 were selected as the study object.They were randomly divided into the control group and the observation group according to the random number table method，with 45 cases in each group.The control group was treated with clopidogrel，and the observation group was prescribed medicine of Yiqi Xiaozheng method，on the basis of the treatment of the control group.The clinical effects of the 2 groups of patients were compared.Serum hs-CRP，TNF-α，and Omentin-1 levels were detected before and after the treatment of both groups.The expression levels of MEK and ERK mRNA were detected by qRT-PCR reaction.Results:The effective rate of the observation group was significantly higher than that of the control group(P<0.05).After the treatment，the cardiac function indexes of both groups were significantly improved(P<0.05).The LVEF of the observation group was significantly higher than that of the control group after treatment，and the LVEDD was significantly lower than that of the control group(P<0.05).The inflammatory factors of the 2 groups were significantly decreased after treatment.The levels of hs-CRP and TNF-α in the observation group were significantly lower than those in the control group(P<0.05).There was no statistical significance of the difference in MEK and ERK levels between the 2 groups before treatment(P>0.05).After treatment，the levels of MEK and ERK in the observation group were significantly lower than those of the control group(P<0.05).There was no significant difference in the levels of Omentin-1 between the 2 groups before treatment(P>0.05)，while the level in both groups was significantly increased after the treatment(P<0.05).The serum Omentin-1 level of the observation group after the treatment was significantly higher than that of the control group(P<0.05).Conclusion:Yiqi Xiaozheng method has better clinical efficacy for coronary heart disease，and can up-regulate serum Omentin-1 level and improve prognosis.Further studies have shown that prescriptions of Yiqi Xiaozheng method can further inhibit the level of MEK/ERK pathways，and reduce the level of inflammatory factors，which may be related to better efficacy.