To explore the clinical study on Xiaoer Jinqiao Granules combined with western medicine in the treatment of acute tonsillitis in children.Methods:A total of 190 cases children of acute tonsillitis admitted in Children's Hospital Affiliated to Zhengzhou University from March 2016 to September 2017 were selected as the research objects.Their clinical data were analyzed retrospectively,and these children were divided into an observation group and a control group according to the different treatments,with 95 cases in each group.The control group was only given western medicine,while the observation group was treated with Xiaoer Jinqiao Granules based on the treatment of the control group.The 2 groups were treated continuously for 7 days.The clinical effects of the 2 groups were compared.The improvement time of clinical symptoms of the 2 groups was calculated.The levels of inflammatory factors and T-lymphocyte subsets in the 2 groups before and after the treatment were detected and compared.Results:The total effective rate of the observation group was 89.47%,which was significantly higher than 77.89% of the control group(P<0.05).In the observation group,the disappearance time of the sore throat,the antipyretic time and the time of tonsil reduction were significantly shorter than those in the control group(P<0.01).After the treatment,the levels of serum IL-6 and TNF-α in the 2 groups were significantly decreased than those before the treatment(P<0.01),and these in the observation group were significantly lower than those in the control group(P<0.01).After the treatment,the proportion of CD4+T lymphocyte subsets and CD4+/CD8+in the 2 groups were significantly increased than those before the treatment,and these in the observation group was significantly higher than those in the control group(P<0.01).The proportion of CD8+T lymphocyte subsets was significantly decreased than that before the treatment,and this in the observation group was significantly lower than that in the control group(P<0.01).Conclusion:On the basis of conventional western medicine,applying Xiaoer Jinqiao Granules can obviously improve the clinical symptoms of children with acute tonsillitis,reduce its inflammatory response,and help to improve its immune function with better curative effect,which is worthy of clinical application.