To clinically study the effects of supplementing kidney and invigorating blood method combined with active immunity on serum Th1 and Th2 cytokines and related hormones in patients with alloimmune recurrent abortion.Methods:From November 2016 to October 2017,161 patients with alloimmune recurrent abortion admitted in Luoyang No.1 Hospital of TCM were selected as research objects and randomly divided into an observation group(n＝82)and a control group(n＝79).The observation group was given supplementing kidney and invigorating blood method combined with simultaneous active immunity,while the control group was only treated with active immunity.The changes of serum Th1 and Th2 cytokines and related hormones in the 2 groups were observed before and after treatment.Results:1)Levels of Th1 and Th2 cytokines:in the observation group after the treatment,IFN-γ(6.65±2.41)ng/L,IL-2(7.13±2.59)ng/L,IL-4(2.66±0.48)ng/L,IL-6(2.75±0.36)ng/L and Th1/Th2(2.98±0.64); in the control group after the treatment,IFN-γ(12.39±2.85)ng/L,IL-2(11.84±3.51)ng/L,IL-4(1.78±0.45)ng· L-1,IL-6(1.57±0.23)ng/L,and Th1/Th2(7.48±2.37).2)Hormone levels:in the observation group after the 3-week treatment,HCG(116812.36±762.35)mIU/mL,P(28.19±3.77)ng/mL,and E2(1250.94±36.27)ng/L; in the control group after the 3-week treatment,HCG(106016.28±725.45)mIU/mL,P(25.67±2.59)ng/mL,and E2(905.81±33.02)ng/L.3)TCM syndrome score:the total score before and after treatment in the observation group was(15.56±0.54)and(3.80±0.24)respectively.The total score before and after treatment in the control group was(15.61±0.39)and(8.85±0.38)respectively.Conclusion:For recurrent abortion of alloimmune type,the therapy of supplementing kidney and invigorating blood method combined with active immunity is clinically effective in improving endocrine and immunomodulatory function of pregnant women.It can reduce the risk of abortion and improve the outcome of pregnancy.