To observe the effects of modified Sanjia Fumai Decoction in the treatment of liver-kidney yin deficiency and menopausal symptoms，as well as its effects on bone mineral density.Methods:A total of 60 patients of liver-kidney yin deficiency and menopausal symptoms were divided into the observation group and the control group according to the randomized controlled clinical trial principle，with 30 patients in each group.The control group was treated orally with tibolone，and the observation group was treated with modified Sanjia Fumai Decoction.After 6 months of treatment，the clinical efficacy of the 2 groups were observed according to the criteria of Kupperman Score，as well as TCM Symptom Score(hot flashes with sweating，insomnia，backache and weakness in legs，irritability，bone and joint pain)，bone mineral density and changes of endocrine hormone levels ［Estradiol(E2)，Follicle-Stimulating Hormone(FSH）and Luteinizing Hormone(LH)］ of the two groups before and after the treatment.Results:The total effective rate of the observation group after treatment was 93.3%，which was significantly higher than that of the control group，and the difference between groups was statistically significant(P<0.05).The TCM Symptom Score of hot flashes with sweating，insomnia，backache and weakness in legs，irritability，bone and joint pain of both group were significantly lowered after the treatment，and that of the observation group was more obvious，whose difference was statistically significant(P<0.05).The serum FSH and LH levels of both group were significantly decreased after treatment，while the E2 levels were significantly increased.The difference in hormone levels before and after treatment was statistically significant(P<0.05)，while there was no significant difference in the above endocrine hormone levels between the 2 groups(P>0.05).The bone mineral density T values of both group were significantly increased after treatment(P<0.05)，and the increase of the observation group was significantly higher than that of the control group; the difference between the two groups was statistically significant(P<0.05).Conclusion:The modified Sanjia Fumai Decoction can effectively improve the vegetative nerve functional disturbance of patients with liver-kidney yin deficiency and menopausal symptoms，increase bone mineral density and significantly improve the clinical symptoms of patients.