To investigate the clinical efficacy of total glucosides of paeony (TGP) on systemic lupus erythematosus (SLE) and its effects on immune function.Methods:A total of 106 patients with SLE in Inner Mongolia Baotou Steel Hospital from March 2015 to May 2018 were divided into an observation group and a control group according to the random number table method,with 53 cases in each group.The control group received conventional treatment,and the observation group added TGP treatment on the basis of the control group.The clinical efficacy,improvement of traditional Chinese medicine (TCM) symptoms after treatment,the scores of SLE disease activity index (SLEDAI) and immune function were compared between the 2 groups after 3 months continuous treatment,and the adverse reactions during the treatment were recorded.Results:After treatment,the total efficiency rate of the observation group was 94.34%,which was significantly higher than 79.25% of the control group (P<0.05).Compared before treatment,the scores of various TCM symptoms significantly decreased after treatment (P<0.05),and the observation group was significantly lower than the control group (P<0.05).The score of SLEDAI significantly decreased after treatment compared with before in the 2 groups (P<0.05),and the observation group was significantly lower than the control group (P<0.01).Compared with before treatment,the ratio of CD4+ in the whole blood of the patients in the control group and the ratio of CD4+ and CD4+/CD8+ in the observation group significantly increased (P<0.05),and the observation group was significantly higher than the control group (P<0.05).There was no significant difference in the incidence of total adverse reactions between the 2 groups (P>0.05).Conclusion:The treatment of SLE with application of TGP based on conventional treatment can significantly improve TCM symptoms,reduce disease activity,improve immune function of patients,enhance treatment efficacy.And there is no increase of the incidence of adverse reactions.