To analyze the changes of inflammatory cytokines in the peripheral blood of patients with phase III diabetic nephropathy before and after the treatment of Yishen Huoxue Xiezhuo decoction combined with Lu's acupuncture and moxibustion.Methods:A total of 90 patients of phase III diabetic nephropathy(CKD1-3 phase; spleen and kidney Qi deficiency and dampness turbid stasis type)admitted to the Seventh People's Hospital of Chinese medicine from January 2017 to December 2018 were selected as subjects.According to the principle of randomized control,they were divided into group A:western medicine control group was given conventional western medicine,group B:Chinese and western medicine treatment group was given Yishen Huoxue Xiezhuo decoction on the basis of western medicine treatment,group C:Chinese and western medicine combined with Lu's acupuncture and moxibustion treatment group on the basis of Chinese and western medicine.All of the 3 groups were treated with 2 months as a course of treatment,a total of 3 courses were treated.The blood glucose FBG,2 hPG,glycosylated hemoglobin HbA1c and other blood glucose indexes and the inflammatory cytokines(MCP-1,TGF-β1,TNF-α)were measured in peripheral blood of 3 groups of subjects.Results:After 3 course of treatment,the blood glucose levels of FBG,2 hPG,glycosylated hemoglobin HbA1c in all 3 groups were improved,and the expression levels of inflammatory cytokines(MCP-1,TGF-β1,TNF-α)were decreased.Compared with the other 2 groups,the improvement effect in group C was statistically significant(P<0.05),and there was significant difference between group A and group B and group C(P<0.05).Conclusion:The expression levels of inflammatory cytokines in the 3 groups are decreased before and after treatment.The expression level of inflammatory cytokines in the Chinese and Western medicine combined with Lu's acupuncture and moxibustion treatment group are the most decreased,and the inflammatory reaction in the body is most obvious.