To explore the clinical efficacy of Jianpi Tiaogan Prescription combined with hormone in the treatment of autoimmune hepatitis and the influence on liver function.Methods:A total of 72 cases of autoimmune hepatitis patients in Shanghai Changning Tianshan Traditional Chinese Medicine Hospital from January 2017 to May 2018 were selected and randomly divided into a control group and an observation group,with 36 cases for each group.The control group was treated with routine symptomatic therapy and hormone therapy,and the observation group was treated combined with Jianpi Tiaogan Prescription on the basis of control group.The 2 groups were treated for 3 months continuously.The clinical efficacy and the traditional Chinese medicine (TCM) syndrome points efficacy in the 2 groups after treatment were evaluated,and the changes of serum liver function indexes and immunoglobulin content in the 2 groups were detected and compared before and after treatment.The occurrence of adverse reaction in the 2 groups during the treatment was recorded.Results:The total clinical effective rate and the total effective rate of TCM syndrome points efficacy in the observation group after treatment were 80.56%,91.67%,which were significantly higher than 58.33%,72.22% in the control group (P<0.05); compared with before treatment,the serum IgG,IgM and IgA contents in the control group after treatment had no significant changes (P>0.05); while the serum ALT,AST,TBIL,GLB,GGT levels in the 2 groups and the IgG,IgM,IgA contents in the observation group decreased significantly,and the observation group was lower than the control group significantly (P<0.05 or P<0.01); no serious adverse reaction occurred during the treatment in the 2 groups.Conclusion:Jianpi Tiaogan Prescription combined with hormone treatment can improve the clinical symptoms of autoimmune hepatitis patients,reduce the serum abnormally elevated immunoglobulin content,restore the liver function effectively and has good safety.The overall efficacy is superior to hormone therapy alone.