To explore the effects of the bone-setting and blood-invigorating method combined with manipulative reduction and external fixation in the treatment of closed fracture of upper limb，and on patients' serum level of inflammatory factors.Methods:From June 2015 to June 2017，a total of 106 patients with upper limb closed fracture treated in People's Hospital of Zhengzhou were selected as study object，and divided into the observation group(53 cases）and the control group(53 cases）according to random number table method.The control group was treated with manipulative reduction and external fixation，and the observation group was treated with the bone-setting and blood-invigorating method in addition to the procedure of the control group.The treatment course of both groups was 12 weeks.The curative effect of the 2 groups，the time of fracture healing，VAS score，the swelling degree score，the X ray score and the level of serum inflammatory factors were compared before and after the treatment.Results:The total effective rate of the observation group(96.23%）was higher than that of the control group(81.13%)(P<0.05).The time of fracture healing of the observation group was faster than that of the control group(P<0.05).After treatment，the score of VAS and the degree of swelling of the 2 groups decreased(P<0.05)，and the score of VAS and the degree of swelling in the observation group were lower than that of the control group(P<0.05).The X-ray score of the 2 groups increased(P<0.05)，and the X-ray score of the observation group was higher than that of the control group(P<0.05).There was no significant change in serum sICAM-1，IL-6 and TNF-α levels of the control group after the treatment(P>0.05).The levels of serum sICAM-1，IL-6 and TNF-α of the observation group decreased(P<0.05)，and the levels of serum sICAM-1，IL-6 and TNF-α of the observation group were lower than those of the control group(P<0.05).Conclusion:The bone-setting and blood-invigorating method combined with manipulative reduction and external fixation is effective in the treatment of closed fractures of upper limb，and it can reduce the inflammatory reaction of patients，which is of important clinical value.