To study the effects of acupuncture combined with nimodipine on hemodynamic state,neurological function and expression of serum TNF-α,TGF-β1 and ICAM-1 in patients with acute cerebral hemorrhage.Methods:A total of 90 cases of acute cerebral hemorrhage patients admitted in The First Affiliated Hospital of Henan University of Chinese Medicine from July 2015 to January 2018 were selected as research subjects,and received conservative treatment.Treatment schemes were retrospectively analyzed and all patients were divided into a control group (n=47) underwent routine symptomatic support treatment and nimodipine,and a acupuncture group (n=43) added acupuncture treatment on the basis of the control group.The hemodynamic state of the 2 groups was monitored before and after treatment.The National Institutes of Health Stroke Scale (NIHSS) score was calculated and serum contents of neuron specific enolase (NSE),brain derived neurotrophic factor (BDNF) were detected.The expression of inflammatory mediator such as tumor necrosis factors α (TNF-α),transforming growth factor β1 (TGF-β1) and intercellular adhesion molecule-1 (ICAM-1) were measured.Results:Before treatment,there were no statistical difference between 2 groups in hemodynamic parameters Vm,RI,PI,score of NIHSS and serum contents of NSE and BDNF,and serum contents of TNF-a,TGF-β1,ICAM-1 (t=0.054,0.236,-0.632,0.455,0.204,0.542,0.111,-0.371,0.189,P>0.05).After 1 course of treatment,levels of Vm and PI in the acupuncture group were higher than those in the control group,and level of RI was lower than that in the control group.Score of NIHSS and serum content of NSE were lower than those in the control group,and content of BDNF was higher than that in the control group; serum contents of TNF-a,TGF-β1 and ICAM-1 in the acupuncture group were lower than those in control group (t=2.025,2.372,-3.318,-14.538,-18.922,11.969,-10.234,-5.166,-8.439,P<0.05).Conclusion:Acupuncture can further optimize the cerebral hemodynamic state of acute cerebral hemorrhage patients,reduce the injury of nerve function and inhibit the excessive inflammatory reaction of the body.It is a reliable means of traditional Chinese medicine treatment.