To study the effects of milled fire needle combined with Bushen Huoxue recipe in the treatment of common type vitiligo patients in advanced stage and its effects on serum soluble intercellular adhesion molecule-1 (sICAM-1) level.Methods:A total of 95 cases of patients with common type vitiligo in advanced stage admitted to Chongqing Traditional Chinese Medicine Hospital from July 2016 to December 2017 were randomly divided into a control group (n=47) and an observation group (n=48).The 2 groups were given Bushen Huoxue Recipe on the basis of routine treatment,and the observation group was treated with milled fire needle on this basis.The 1 course of treatment was 4 weeks,and all had 3 courses treatment continuously.The clinical effect of the 2 groups were statistically analyzed,and the improvement of the skin lesion area of vitiligo before and after treatment in the 2 groups were compared,and the levels of serum sICAM-1,IFN-γ,GM-CSF and Treg cells ratio before and after treatment were compared.Adverse reactions of the 2 groups were recorded during the treatment period.Results:The onset time of control group and observation group were (25.46±10.36) d,(18.59±9.63) d respectively,and observation group was significantly shorter than the control group (P<0.01).After treatment,the area of vitiligo skin lesions in both groups decreased,and the improvement effect of observation group was better than that of control group (P<0.01).The total effective rate of the observation group was significantly higher than that of the control group (95.83% vs 70.21%,P<0.01).Compared with before treatment,the levels of serum sICAM-1 and IFN-γ in the 2 groups decreased after treatment,and the observation group was lower than the control group (P<0.01).The proportion of CD4+ CD25+Treg cells in the 2 groups increased and the content of GM-CSF decreased compared with before treatment (P<0.01),and the proportion of CD4+ CD25+Treg cells in the observation group was higher than that of the control group,and the content of GM-CSF was lower than that of the control group (P<0.01).There was no significant difference in the incidence of adverse reactions between the 2 groups (25.00% vs 12.50%,P>0.05).Conclusion:Milled fire needle combined with Bushen Huoxue recipe is effective in the treatment of common type vitiligo patients in advanced stage.It can reduce the expression of serum inflammatory cytokines such as sICAM-1 and IFN-γ,modulate the immune function of the patients and postpone the progress of the disease,and the safety is better.