To observe the effects of triptolide microemulsion gel(TP-MBGs）on the expression of T cell related factors in CIA rats,and to explore the mechanism of its treatment of rheumatoid arthritis.Methods：A total of 56 CIA rats were randomly divided into a blank group,a model group,a matrix group,a TP intragastric administration group,a TP microemulsion high dose group,a TP-MBGs high,middle and low dose group.After 28 days of administration,the expression level of the rat skin of CD1α,IgA,the serum of IFN-γ,IL-6,TNF-α,ColⅡ,IL-10 and the synovial cell supernatant of IL-1,PGE2,TNF-α were detected by ELISA.Results：Compared with the blank control group,the expression of CD1α in skin,IFN-γ,IL-6,TNF-α in serum and IL-1,PGE2,TNF-α in synovial cell supernatant were significantly increased in the model group.Compared with the model group,the expression levels of TNF-α and IL-6 in serum,IL-1 and TNF-α in the supernatant of synovial cells in the middle dose TP-MBGs group were significantly decreased than those in the model group.The expression of CD1α in skin,TNF-α and IFN-γ in serum,IL-1 and TNF-α in synovial cell supernatant decreased significantly in high dose TP-MBGs group.Conclusion：Tripterygium wilfordii microemulsion gel for external treatment of rheumatoid arthritis may play a local and systemic role by regulating skin immune function and inhibiting the secretion of related cytokines.