Damp-heat syndrome is a common clinical syndrome accompanied by specific gastrointestinal symptoms,suggesting the potential unique intestinal microecological characteristics of patients with damp-heat syndrome.Explaining the material basis and pathological mechanism of damp-heat syndrome is of great significance for interpreting the connotation of traditional Chinese medicine(TCM）syndromes.Taking common chronic liver disease as an example,authors put forward that the research on intestinal microecology of damp-heat syndrome should be based on clinical practice and set up a control group,meanwhile the characteristics and similarities of damp-heat syndrome should be explored through the comparison of different syndromes of the same disease and the same syndrome of different diseases.The authors also believe that the causal relationship between intestinal microecology and damp-heat syndrome can be explored through modern scientific and technological means such as flora transplantation in sterile mice,which can provide an effective method for syndrome research and exploration.