To observe the effects of self-made Wenyang Xiaoyin Decoction on liver and kidney function protection,hemodynamic indexes and peripheral blood tumor necrosis factor-α(TNF-α),nitric oxide(NO）and soluble cell adhesion factor-1(sICAM-1）levels in treating spleen-kidney yang deficiency syndrome patients with liver cirrhosis and hepatorenal syndrome.Methods：A total of 102 patients with liver cirrhosis and hepatorenal syndrome admitted in Cangzhou Infectious Diseases Hospital from February 2016 to January 2018 were selected as research objects,and randomly divided into control group and observation group,with 51 cases in each group.Patients in the control group were treated with alprostadil injections for intravenous drip,while patients in the observation group were treated with self-made Wenyang Xiaoyin Decoction orally on the treatment basis of the control group.Clinical efficacy was compared,changes biochemical indicators related toliver and kidney function were detected,portal hemodynamic changes were observed,and the levels of TNF-α,NO and sICAM-1 in peripheral blood were monitored.Results：The effective rate of the observation group was 88.23%,which was significantly higher than 70.59% in the control group(χ2 = 6.074,P<0.05); after the treatment,the levels of ALT,AST and TBiL of patients in the observation group were significantly lower than those in the control group,and the Alb level was significantly increased(P<0.05); the levels of renal function related indicators like 24 h urine protein quantitation(UPR),BUN,β2-MG and SCr was significantly lower than those in the control group(P<0.05); the levels of hemodynamic indicators like PVD,SVD,PVQ and SVQ of the portal vein and splenic vein in the observation group were significantly lower than those in the control group(P<0.05); the levels of TNF-α,NO and sICAM-1 in peripheral blood were significantly lower than those in the control group(P<0.05).Conclusion：Adding self-made Wenyang Xiaoyin Decoction is good to improve liver and kidney function,narrow the inner diameter of the portal vein and reduce the blood flow.The mechanism may be associated with regulating the serum levels of TNF-α,NO and sICAM-1 to alleviate the local inflammatory injury,improve blood circulation in the liver,reduce portal vascular resistance and play the role of liver and kidney protection.