To explore the clinical effects of Biyuan Tongqiao Granule combined with clarithromycin in children with chronic sinusitis and its influence on inflammatory factors.Methods：A total of 121 children with chronic sinusitis treated in Ruijin Hospital Affiliated to Medical College of Shanghai Jiaotong University from July 2016 to May 2018 were divided into an observation group(n＝60)and a control group(n＝61)according to random number table.The control group was treated with clarithromycin,while the observation group was additionally treated with Biyuan Tongqiao Granule on this basis.The scores of therapeutic effect,the levels of inflammatory factors,nasal mucociliary transport rate(MTR),nasal mucociliary clearance rate(MCC)and effective rate were compared between the 2 groups.Results：The effective rate in the observation group was 91.67%,which was significantly higher than 70.00% in the control group(P<0.05).After treatment,the scores of visual analogue scale(VAS),endoscopic mucosal morphology,sinus CT scan lesion,the levels of IL-2 and IL-6 in the 2 groups all decreased(P<0.05),and the observation group was lower than those in the control group,with statistical differences(P<0.05).After treatment,the levels of MTR and MCC in both groups increased(P<0.05),and the observation group was higher than those in the control group(P<0.05).Conclusion：Biyuan Tongqiao Granule combined with clarithromycin can improve the clinical symptoms of chronic sinusitis in children by reducing the level of inflammation and enhancing the ciliary function of nasal mucosa.