To explore the clinical efficacy of Shugan Jieyu Capsules in post-stroke depression and its effects on the levels of norepinephrine(NE）and 5-hydroxytryptamine(5-HT),so as to enrich the treatment methods,improve the efficacy and reduce the influence of depression.Methods：A total of 118 patients with post-stroke depression treated in Shunyi Hospital of Beijing Hospital of Traditional Chinese Medicine from January 2017 to January 2018 were selected as research objects,and according to their numbers,they were randomly divided into control group(59 cases）and observation group(59 cases).The control group was treated with conventional western medicine,while the observation group was treated with conventional western medicine and Shugan Jieyu Capsules.The 2 groups were treated for 4 weeks.The levels of brain-derived neurotrophic factor(BDNF),nerve growth factor(NGF),dopamine(DA),5-hydroxytryptamine(5-HT）and norepinephrine(NE）in serum of the 2 groups before and after the treatment were observed and compared.The levels of tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β）and homocysteine(HCY）of the 2 groups before and after the treatment were observed and compared.The changes of Hamilton Depression Scale(HAMD),Self-rating Depression Scale(SDS),Activity of Daily Living Scale(ADL）and Neurological Functional Deficit Scale(NFDS）were observed and compared before and after the treatment,and the adverse reactions including gastrointestinal reaction,loss of appetite,dry stool,tremor,etc were monitored.Results：There was no significant difference in HCY,TNF-α and IL-1β between the 2 groups before the treatment(P>0.05).After the treatment,the above indexes of the 2 groups were significantly lower than those before the treatment(P<0.05).After the treatment,the above indexes of the observation group were significantly lower than those of the control group(P<0.05).(2）There was no significant difference in BDNF,NGF,DA,5-HT and NE between the 2 groups before the treatment(P>0.05).After the treatment,the above indexes in the 2 groups were significantly higher than those before the treatment(P<0.05).After the treatment,the above indexes in the observation group were significantly higher than those in the control group(P<0.05).(3）There was no significant difference in the scores of HAMD,SDS,ADL and NFDS between the 2 groups before the treatment(P>0.05).After the treatment,the scores of HAMD,SDS and NFDS in the 2 groups were decreased significantly and the score of ADL was increased significantly,compared with those before the treatment(P<0.05).After the treatment,the above indexes in the observation group were significantly better than those in the control group(P<0.05).The incidence of adverse reactions was 8.47% in the control group and 6.78% in the observation group.There was no significant difference between the 2 groups(P>0.05).Conclusion：Shugan Jieyu Capsules can reduce the degree of post-stroke depression,increase the levels of NE and 5-HT,inhibit inflammation,and improve the efficacy.