To observe the therapeutic effect of invigorating spleen and regulating qi Chinese Medicine on dyspepsia of liver depression and spleen deficiency syndrome，and study the change of the indexes of plasma gastrin，motilin，cholecystokinin and ghrelin in the body.Methods：A total of 104 patients with dyspepsia of liver depression and spleen deficiency syndrome treated by traditional Chinese medicine from July 2016 to October 2017 in Central Hospital Affiliated to Qingdao University were chosen.They were divided into a control group and an observation group according to the principle of voluntary treatment，and 52 cases in each group.The patients in the control group were treated with western medicine(oral domperidone tablets+ranitidine capsules).The patients in the observation group were treated with traditional Chinese medicine(Shugan Jianpi Decoction).14 days were as one course of treatment，and last for 6 consecutive courses.The clinical effects of the 2 groups of patients were observed.The changes of the levels of plasma gastrin，motilin，cholecystokinin and ghrelin in patients before and after treatment were statistically analyzed.Results：1）The total effective rate of the control group after treatment was 75.00%(39/52)，and the total effective rate of the observation group was 92.31%(48/52).The differences were with statistical significance in the 2 sets of data results(P<0.05).2）There were no differences in plasma gastrin(GAS)and motilin(MTL)between the 2 groups before treatment(P>0.05).After treatment，the GAS and MTL values in the control group were(41.8±5.7)pg/mL，(227.8±7.4)pg/mL.The GAS in the observation group was(44.7±5.4)pg/mL and the MTL was(241.7±8.5)pg/mL after treatment.There were statistical differences compared between the 2 groups(P<0.05).3）There were no statistical significance of CCK and Ghrelin in the 2 groups before treatment(P>0.05).The CCK values in the control and observation groups after treatment were(65.32±4.24)(71.06±5.23)pg/mL and Ghrelin were(231.04±23.64)pg/mL and(253.45±24.52)pg/mL respectively，all of which were with statistical significance(all P<0.05).Conclusion：Invigorating spleen and regulating qi Chinese Medicine can effectively improve the symptoms of patients with dyspepsia due to liver depression and spleen deficiency，promote the secretion of motilin and gastrin，improve the level of gastric somatotropin，increase the appetite of patients and increase the gallbladder's function of contraction，enhance immune function and improve the quality of life of patients.