To investigate the curative effects of Yinlian Huazhuo Jiedu Decoction combined with ERCP in the treatment of choledocholithiasis,and to evaluate the levels of biliary biochemical indexes,liver function indexes and recurrence rate of stones.Methods：A total of 100 cases of choledocholithiasis patients underwent ERCP treatment in Hebei Provincial Hospital of Traditional Chinese Medicine during September 2016 to July 2018 were chosen as research subjects,and they were divided into a control group(n=50,underwent ERCP+routine intervention after operation),an observation group(n=50,underwent ERCP+Yinlian Huazhuo Jiedu Decoction after operation).The curative effects were evaluated 7 days after operation.Results：On 7th day after operation,the scores of abdominal pain,fever and jaundice in the observation group were decreased than those in the control group; levels of total bile acid(TBA),total bilirubin(TBil),direct bilirubin(DBil）and indirect bilirubin(IBil）in peripheral blood were lower than those in the control group; levels of AST,ALT and γ-GT in peripheral blood were lower than those in the control group(P<0.05).During follow-up period,there was no significant difference in stone recurrence rate between the 2 groups(P>0.05).Conclusion：The combination of Yinlian Huazhuo Jiedu Decoction after ERCP in the treatment of choledocholithiasis is helpful to further optimize the patients' short-term condition and has good medication safety.