To investigate the effects of Puerarin Injection combined with Sodium tanshinone II A sulfonate on chronic congestive heart failure(CHF)patients and their influence on plasma PRA and ALD.Methods：According to the random number table method，90 cases of CHF patients admitted in Lu'an Traditional Chinese Medicine Hospital from February 2015 to September 2017 were divided into a control group(n=45)and an observation group(n=45).Patients in the control group were treated with western medicine combined with Sodium tanshinone II A sulfonate，while those in the observation group were treated with Puerarin Injection on the basis of the control group，both lasted for 30 d.The difference in short-term curative effect，level of cardiac function indexes and plasma PRA，ALD between the 2 groups were compared.Results：Thirty days after treatment，total effective rate in the observation group was higher than that in the control group; and levels of cardiac function indexes such as CO，LVEF were higher than those in the control group.Levels of LVEDD，LVESD in the observation group were lower than those in the control group; plasma PRA and ALD levels in the observation group were lower than those in the control group，and the differences of above indexes were statistically significant(P<0.05).Conclusion：Combination of Puerarin Injection basing on western medicine and Sodium tanshinone II A sulfonate，can further improve CHF patients short-term curative effect，actively change the heart function and coordinate the state of the body's neuroendocrine.