To explore the effects of Shixiao Powder combined with endoscopic thyroidectomy on the postoperative incision effusion and pain of patients with thyroid tumors.Methods：A total of 66 patients with thyroid tumors in People's Hospital of Dongxihu District from January 2016 to February 2018 were selected and divided randomly into a control group and an observation group according to random number table,with 33 cases in each group.The 2 groups were treated with endoscopic thyroidectomy.The control group was treated with regular treatment post-operation,and the observation group was treated with Shixiao Powder on the basis of the control group post-operation.They were treated for 2 weeks continuously.The clinical efficacy in 2 groups was statisticsed in 2 weeks and 1 month post-operation; the changes of neck drainage,pain degree and serum inflammatory factors at different time's operation in 2 groups were detected and compared.Results：The total effective rates of the observation group in 2 weeks,1 month post-operation were 66.76%,93.94% respectively,which were significantly higher than 36.36%,69.70% of the control group(P<0.05 or P<0.01); The neck drainage,VAS scores and serum CRP,IL-6 levels of patients in the 2 groups at 1 to 5 d post-operation decreased gradually,and the observation group was significantly lower than the control group at 3,5 d post-operation(P<0.01).Conclusion：Shixiao Powder combined with endoscopic thyroidectomy can effectively ease the postoperative pain of patients with thyroid tumors,relieve the postoperative inflammatory reaction and then reduce surgical discharge.The clinical efficacy is better than routine postoperative treatment.