To explore the effects of acupuncture at Yanglao(SI 6）combined with rehabilitation exercise on the quality of life of shoulder-hand syndrome after stroke,and to explore the mechanism of action in order to improve the efficacy.Methods：From April 2016 to January 2018,86 patients with post-stroke shoulder-hand syndrome admitted in Dazhou Central Hospital and eligible for inclusion were selected as research subjects.They were randomly divided into control group(43 cases）and observation group(43 cases）according to the order of treatment.The control group received routine treatment：basic treatment such as regulating blood pressure,blood lipid and anti-platelet aggregation,health education and electroacupuncture.On the treatment basis of the control group,the observation group was given acupuncture at Yanglao(SI 6）combined with rehabilitation exercise for 8 weeks.Levels of calcitonin gene-related peptide(CGRP),nitric oxide(NO),plasma endothelin-1(ET-1),bradykinin(BK）and substance P(SP）in the 2 groups were observed and compared before and after the treatment.Before and after the treatment,the changes of hemorheology indexes like whole blood reduced viscosity,plasma viscosity,hematocrit and platelet aggregation rate in the 2 groups were observed and compared.VAS score,FMA score and MBI score in the 2 groups were observed and compared before and after the treatment.Adverse reactions were monitored during the treatment.Hematological indexes of blood routine test and liver and kidney function were detected.The efficacy was summarized after the treatment.Results：There was no significant difference in CGRP,NO,ET-1,BK and SP between the 2 groups before the treatment(P>0.05).After the treatment,the content of CGRP and NO in the 2 groups was significantly higher than that before the treatment,while the content of ET-1,BK and SP was significantly lower than that before the treatment(P<0.05).After the treatment,the content of CGRP and NO in the observation group was significantly higher than that in the control group,while the content of ET-1,BK and SP was significantly lower than that in the control group(P<0.05).(2）There was no significant difference in the whole blood reduction viscosity,plasma viscosity,hematocrit and platelet aggregation rate between the 2 groups before the treatment(P>0.05).After the treatment,the above indexes in the 2 groups were significantly lower than those before the treatment(P<0.05).After the treatment,the above indexes in the observation group were significantly lower than those in the control group(P<0.05).(3）The VAS,FMA and MBI scores of the 2 groups were not statistically significant before the treatment(P>0.05).After the treatment,the VAS and FMA scores of the 2 groups were significantly lower than those before the treatment,and the MBI scores were significantly higher(P<0.05).After the treatment,the VAS and FMA scores of the observation group were significantly lower than those of the control group,and the MBI score was significantly higher than that of the control group(P<0.05).(4）After the treatment,the effective rate and total effective rate of the observation group were significantly higher than those of the control group(P<0.05).(5）The incidence of adverse reactions was 11.63 in the control group and 9.3 in the study group.There was no significant difference in the incidence of adverse reactions between the 2 groups(P>0.05).Conclusion：Acupuncture at Yanglao(SI 6）combined with rehabilitation exercise can improve the quality of life and efficacy of shoulder-hand syndrome after stroke,inhibit inflammatory reaction,improve endothelial function and promote blood circulation.